Problems in cancer research at Baylor College of Medicine are broadly distributed in the Departments of Pharmacology, Virology, Cell Biology, Experimental Biology, Medicine, Pathology and other Departments. This application is a request for an extension and expansion of the Baylor Cancer Research Center to include an increased number of areas of research. It is hoped that these studies will provide useful information for clinical approaches to chemotherapy, immunotherapy and improved diagnosis, as well as development of a broad base of understanding of the molecular biology and pathogenesis of cancer.